Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
| Autor: | Denis R. Morel, Fabienne Fontao, Walid Habre, Ferenz Petak, Eniko Lele |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Methyl Ethers Minimum alveolar concentration Bronchoconstriction Blood Pressure In Vitro Techniques Pharmacology Sevoflurane Desflurane Airway resistance Heart Rate medicine Animals Lung Isoflurane Inhalation business.industry Airway Resistance General Medicine respiratory system Denervation Acetylcholine Rats Anesthesiology and Pain Medicine Anesthesia Anesthetics Inhalation Respiratory Mechanics Halothane medicine.symptom business Algorithms medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 50:1145-1151 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.2006.01133.x |
| Popis: | Background: Bronchoactive properties of volatile agents against lung constriction are well established. The purpose of this study was to investigate the ability of halothane (Hal), isoflurane (Iso), sevoflurane (Sev) and desflurane (Des) to alter the lung mechanics in the absence of an airway tone and during acetylcholine (Ach)-induced bronchoconstriction. Methods: Low-frequency pulmonary impedance data (ZL) were collected from isolated, normo-perfused rat lungs under baseline conditions and following the injection of Ach (0.1 mg/kg) into the pulmonary artery. Measurements were performed without the administration of any anaesthetic agent in the first phase of the experiments and during inhalation without any volatile agent (control group, n = 6) or during inhalation of Hal (n = 6), Iso (n = 9), Sev (n = 6) or Des (n = 8) at 1 minimum alveolar concentration (MAC). The airway resistance (Raw) and parenchymal damping and elastance were estimated from the ZL data by model fitting. Results: Under baseline conditions, the basic value of Raw was significantly decreased by Des (− 31.2 ± 3.8%) and Sev (− 18.0 ± 4.5%) administration, whereas Hal and Iso did not have a statistically significant effect on Raw (− 3.3 ± 5.1% and − 8.6 ± 2.4%, respectively). Moreover, all four inhalation anaesthetics prevented the increase in Raw following Ach administration, the findings ranging between − 14.3 ± 11.4% for Hal and − 37.5 ± 10.9% for Sev. Conclusions: Our results on a denervated isolated perfused lung model demonstrate the potential of Des and Sev to decrease the basal airway tone, whereas Iso and Hal are ineffective in this regard. All of these volatile agents markedly protect against Ach-induced bronchoconstriction. |
| Databáze: | OpenAIRE |
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