Near-infrared fluorescent coatings of medical devices for image-guided surgery

Autor: Bohdan Andreiuk, Anila Hoskere Ashoka, Barbara Seeliger, Michele Diana, Andrey S. Klymchenko, Seong Ho Kong, Renato V. Soares, Manuel Barberio
Přispěvatelé: L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Indocyanine Green
Materials science
image-guided surgery
Polymers
Swine
Biophysics
Bioengineering
02 engineering and technology
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
engineering.material
near-infrared dyes
Buffer (optical fiber)
medical devices
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Silicone
Coating
Animals
Humans
Methyl methacrylate
Near-infrared fluorescent coatings
Fluorescent Dyes
030304 developmental biology
dye-doped polymeric materials
0303 health sciences
Near-infrared spectroscopy
[CHIM.MATE]Chemical Sciences/Material chemistry
021001 nanoscience & nanotechnology
Fluorescence
Image-guided surgery
Surgery
Computer-Assisted
chemistry
Mechanics of Materials
Ceramics and Composites
engineering
0210 nano-technology
Indocyanine green
Biomedical engineering
Zdroj: Biomaterials
Biomaterials, Elsevier, 2020, 261, pp.120306. ⟨10.1016/j.biomaterials.2020.120306⟩
Biomaterials, 2020, 261, pp.120306. ⟨10.1016/j.biomaterials.2020.120306⟩
ISSN: 0142-9612
Popis: International audience; Rapidly expanding field of image-guided surgery needs new materials for near-infrared imaging with deep tissue penetration. Here, we introduce near-infrared coating of equipment (NICE) for image-guided surgery based on a series of lipophilic cyanine-7.5 dyes with bulky hydrophobic counterions and a biocompatible polymer, poly(methyl methacrylate). The NICE material exhibits superior brightness (15-20-fold higher) and photostability compared to fluorescent coatings based on commonly used indocyanine green (ICG). It can be deposited on different surfaces and devices, such as steel and gold fiducials, silicone and PVC catheters, polymeric surgical sutures and gauzes. Such coated medical devices show excellent stability in air and buffer for 150 days. Accelerated ageing revealed their shelf-life of 3 years. They are also stable in serum-containing media, whereas ICG-based coating shows rapid dye leakage. NICE is compatible with standard sterilization protocols based on ethylene oxide and vapor. Moreover, our coating material is biocompatible, where cultured cells spread effectively without signs of cytotoxicity. Ex vivo studies suggest that NICE on fiducials can be visualized as deep as 0.5 cm, and NICE on catheters enables their visualization inside ureters and esophagus. Finally, NICE on different medical devices has been validated for image-guided surgery in porcine and human cadaver models. Thus, the developed NIR coating material emerges as a powerful tool for a variety of medical applications.
Databáze: OpenAIRE
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