The effects of chlormadinone acetate upon estradiol uptake by the rat mammary gland in organ culture
| Autor: | Greta Declercq de Pérez Bedés |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Chlormadinone Acetate Mammary gland Biology Acetates Organ culture Tritium Binding Competitive Chlormadinone acetate chemistry.chemical_compound Mammary Glands Animal Organ Culture Techniques Internal medicine medicine Endocrine system Animals Binding Sites Estradiol Obstetrics and Gynecology Drug Synergism Antiestrogen In vitro Rats Endocrinology medicine.anatomical_structure chemistry Hormone receptor Research Design Female Hormone |
| Zdroj: | American journal of obstetrics and gynecology. 118(8) |
| ISSN: | 0002-9378 |
| Popis: | Chlormadinone acetate (CAP) was found to inhibit the uptake of 3 H-estradiol-17β (E 2 ) by rat mammary glands in organ culture when 3 H-E 2 was added simultaneously with CAP, suggesting that CAP may act as an antiestrogen by competing with E 2 for the binding sites. However, when CAP was added 24 hours before 3 H-E 2 , uptake was increased. These results suggest a mechanism by which CAP may, by enhancing the binding of E 2 in the mammary gland, exert estrogenic action. |
| Databáze: | OpenAIRE |
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