Immunohistochemistry and scoring of Ki-67 proliferative index and p53 expression in gastric B cell lymphoma from Northern African population: a pilot study
| Autor: | Meriem N Mrabent, Feriel Sellam, Abdelnacer Tou, Noria Harir, Soumia Zeggai, Rachida Salah |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Proliferation index biology Proliferative index business.industry Gastric lymphoma Gastroenterology 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology hemic and lymphatic diseases 030220 oncology & carcinogenesis Ki-67 biology.protein Medicine Immunohistochemistry Original Article business B-cell lymphoma P53 expression B cell |
| Zdroj: | Journal of gastrointestinal oncology. 7(3) |
| ISSN: | 2078-6891 |
| Popis: | Background: This study aimed to clarify the Ki-67 distribution, p53 expression and their relationship with clinico-pathologic features of gastric B cell lymphoma from Northern African population. Methods: Twenty paraffin blocks of gastric lymphoma were retrieved from the archival materials of Department of Pathology, Central University Hospital of Sidi Bel Abbes (Western Algeria) from 2007 to 2013. Four μm section specimens were stained by immunohistochemical (IHC) technique with Ki-67 and p53 tumor markers. P values Results: Expression of p53 proteins and the mean proliferative index (PI) were compared between high grade gastric B cell lymphomas (DLBCL) and low grade gastric B cell lymphomas (gastric MALTs). p53 overexpression (P=0.007) and a high proliferation index Ki-67 (P=0.001) were significantly associated with gastric DLBCL. We found also a statistically significant correlation between p53 and Ki-67 (P=0.007) but no obvious relationships were found between Ki-67 PI and p53 expression as well as clinico-pathological features (age, sex, location, macroscopic type). Conclusions: The IHC studies of Ki-67 and p53 expression in gastric B cell lymphoma can help in monitoring of patients at risk, and to give suitable treatment and management of patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|