Cerebral amyloid accumulation is associated with distinct structural and functional alterations in the brain of depressed elders with mild cognitive impairment
| Autor: | Byung Joo Ham, Cheol E. Han, Suji Lee, Hyun Chul Youn, June Kang, Junhyung Kim, Hyun Ghang Jeong, Sang Il Suh, Changsu Han, Won Seok William Hyung |
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| Rok vydání: | 2021 |
| Předmět: |
Amyloid
medicine.medical_specialty Disease behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine mental disorders medicine Humans Cognitive Dysfunction Florbetaben Aged Depressive Disorder Major medicine.diagnostic_test business.industry Brain Cognition Voxel-based morphometry Late life depression medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Clinical Psychology Positron emission tomography Positron-Emission Tomography Cardiology Major depressive disorder business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 281:459-466 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2020.12.049 |
| Popis: | Background Elderly patients with late-life depression (LLD) often report mild cognitive impairment (MCI), so Alzheimer's disease (AD) is hard to identify in these patients. We aimed to identify the structural and functional differences between prodromal AD and LLD-related MCI. Methods We performed voxel-based morphometry and functional connectivity (FC) analyses in elderly patients with both LLD and MCI to compare alterations between those with cerebral amyloidopathy and those without. We subdivided patients into subthreshold depression (STD) and major depressive disorder (MDD) groups. Using florbetaben positron emission tomography (PET), we compared volume and connectivity between healthy controls and four STD and MDD groups with or without amyloid deposition(A): STD-MCI-A(+), MDD-MCI-A(+), STD-MCI-A(-), and MDD-MCI-A(-). Results Subjects with MDD or amyloid deposition showed greater volume reduction in the left middle temporal gyrus. MDD groups had lower FC than STD groups in the frontal, cortical, and limbic areas. The STD-MCI-A(+) group showed greater FC reduction than the MDD-MCI-A(-) and STD-MCI-A(-) groups, particularly in the hippocampus, parahippocampus, and frontal and temporal cortices. The functional differences associated with amyloid plaques were more evident in the STD group than in the MDD group. Limitations Limitations include disproportional sex ratios, inability to determine the longitudinal effects of amyloidopathy in large populations. Conclusions Regional gray matter loss and alterations in brain networks may reflect impairments caused by amyloid deposition and depression. Such changes may facilitate the detection of prodromal AD in elderly patients with both depression and cognitive dysfunction, allowing earlier intervention and more appropriate treatment. |
| Databáze: | OpenAIRE |
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