Frequent retinal ganglion cell damage after acute optic neuritis
| Autor: | Hanna Zimmermann, Friedemann Paul, Fiona Costello, Alexander U. Brandt, Timm Oberwahrenbrock, Svenja Specovius |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty Optic Neuritis Visual acuity genetic structures Visual Acuity 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans Optic neuritis Cell Death business.industry Multiple sclerosis Organ Size General Medicine Prognosis medicine.disease Inner plexiform layer eye diseases Cell loss Ganglion Visual field medicine.anatomical_structure Neurology Retinal ganglion cell Multivariate Analysis 030221 ophthalmology & optometry Female sense organs Neurology (clinical) medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Multiple Sclerosis and Related Disorders. 22:141-147 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2018.04.006 |
| Popis: | Background To identify the extent of ganglion cell damage after first-time optic neuritis (ON) using the inter-ocular difference between affected and fellow eyes, and whether this approach is able to detect more patients suffering from ganglion cell damage than using absolute values. Methods Thirty-four patients with first-time unilateral ON were followed for a median 413 days. Patients underwent optical coherence tomography testing to determine ganglion cell plus inner plexiform layer thickness (GCIP). Ganglion cell loss was quantified as GCIP difference between ON-affected and fellow eyes (inter-GCIP) and was compared against measurements from 93 healthy controls (HC). Visual function was assessed with high contrast visual acuity; and standard automated perimetry-derived measures of mean deviation and foveal threshold. Results At clinical presentation after median 19 days from symptom onset, 47.1% of patients showed early GCIP thinning in the ON-affected eye based on inter-GCIP. At the last visit acute ON was associated with 16.1 ± 10.0 µm GCIP thinning compared to fellow eyes (p = 3.669e-06). Based on inter-GCIP, 84.9% of ON patients sustained GCIP thinning in their affected eye at the last visit, whereas using absolute values only 71.0% of patients suffered from GCIP thinning (p = 0.002076). Only 32.3% of these patients had abnormal visual function. The best predictor of GCIP thinning as a measure of ON severity at the last visit was worse visual field mean deviation at clinical presentation. Conclusion Inter-ocular GCIP identifies significantly more eyes suffering damage from ON than absolute GCIP, visual fields or visual acuity loss. Effective interventional options are needed to prevent ganglion cell loss. |
| Databáze: | OpenAIRE |
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