A Comparison of the Hot Spot and the Average Cancer Cell Counting Methods and the Optimal Cutoff Point of the Ki-67 Index for Luminal Type Breast Cancer
| Autor: | Mamiko Fujisue, Yasuo Toyozumi, Tomofumi Osako, Reiki Nishimura, Nobuyuki Arima, Masahiro Nakano, Yasuyuki Nishiyama, Yasuhiro Okumura, Rumiko Tashima |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Index (economics) Breast Neoplasms Hot spot (veterinary medicine) Disease-Free Survival Breast cancer Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans Point (geometry) Aged Neoplasm Staging biology business.industry General Medicine Middle Aged Prognosis Cell counting medicine.disease Immunohistochemistry Ki-67 Antigen Receptors Estrogen Case-Control Studies Lymphatic Metastasis Predictive value of tests Ki-67 Cancer cell biology.protein Female Lymph Nodes Neoplasm Recurrence Local Receptors Progesterone business Nuclear medicine |
| Zdroj: | Oncology. 90:43-50 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Objective: In this case-control study, we investigated the most suitable cell counting area and the optimal cutoff point of the Ki-67 index. Methods: Thirty recurrent cases were selected among hormone receptor (HR)-positive/HER2-negative breast cancer patients. As controls, 90 nonrecurrent cases were randomly selected by allotting 3 controls to each recurrent case based on the following criteria: age, nodal status, tumor size, and adjuvant endocrine therapy alone. Both the hot spot and the average area of the tumor were evaluated on a Ki-67 immunostaining slide. Results: The median Ki-67 index value at the hot spot and average area were 25.0 and 14.5%, respectively. Irrespective of the area counted, the Ki-67 index value was significantly higher in all of the recurrent cases (p < 0.0001). The multivariate analysis revealed that the Ki-67 index value of 20% at the hot spot was the most suitable cutoff point for predicting recurrence. Moreover, higher ΔKi-67 index value (the difference between the hot spot and the average area, ≥10%) and lower progesterone receptor expression (Conclusion: A higher Ki-67 index value at the hot spot strongly correlated with recurrence, and the optimal cutoff point was found to be 20%. |
| Databáze: | OpenAIRE |
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