Prevention of hemorrhage-induced renal vasoconstriction and hypoxia by angiotensin II type 1 receptor antagonism in pigs
| Autor: | Erik Näslund, Stephanie Franzén, Robert Frithiof, Helen Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Swine Physiology Hemorrhage 030204 cardiovascular system & hematology Kidney Losartan 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Animals Hypoxia Receptor business.industry Hemodynamics Hypoxia (medical) Angiotensin II Oxygen Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology Vasoconstriction Renal blood flow cardiovascular system Hypotension medicine.symptom business Antagonism Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 321:R12-R20 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Angiotensin II (ANG II) is a potent vasoconstrictor and may reduce renal blood flow (RBF), causing renal hypoxia. Hypotensive hemorrhage elevates plasma ANG II levels and is associated with increased risk of acute kidney injury. We hypothesized that ANG II antagonism prevents renal vasoconstriction and hypoxia caused by hemorrhage. Pigs were anaesthetized, surgically prepared, and randomized to intravenous losartan (1.5 mg·kg−1·h−1, n = 8) or an equal volume of intravenous Ringer acetate (vehicle-treated, n = 8). Hemorrhage was induced by continuous aspiration of blood to reach and sustain mean arterial pressure of |
| Databáze: | OpenAIRE |
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