Engineering Microphysiological Immune System Responses on Chips
| Autor: | Deok Ho Kim, Eun Hyun Ahn, Chris P. Miller, Hyun-Jung Kim, Woojung Shin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Systems immunology Microfluidics Immunity Bioengineering 02 engineering and technology Biology 021001 nanoscience & nanotechnology Article 03 medical and health sciences Crosstalk (biology) 030104 developmental biology Immune system Intestinal inflammation Immune System Lab-On-A-Chip Devices Neoplasms Tumor Microenvironment Humans 0210 nano-technology Neuroscience Mucosal immunity Biotechnology |
| Zdroj: | Trends Biotechnol |
| ISSN: | 0167-7799 |
| Popis: | Tissues- and organs-on-chips are microphysiological systems (MPSs) that model the architectural and functional complexity of human tissues and organs that is lacking in conventional cell monolayer cultures. While substantial progress has been made in a variety of tissues and organs, chips recapitulating immune responses have not advanced as rapidly. This review discusses recent progress in MPSs for the investigation of immune responses. To illustrate recent developments, we focus on two cases in point: immunocompetent tumor microenvironment-on-a-chip devices that incorporate stromal and immune cell components and pathomimetic modeling of human mucosal immunity and inflammatory crosstalk. More broadly, we discuss the development of systems immunology-on-a-chip devices that integrate microfluidic engineering approaches with high-throughput omics measurements and emerging immunological applications of MPSs. |
| Databáze: | OpenAIRE |
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