Health‐related quality of life in Norwegian adults with Fabry disease: Disease severity, pain, fatigue and psychological distress
| Autor: | Charlotte von der Lippe, Trond Jenssen, Hege Pihlstrøm, Olga Solberg, Dag Olav Dahle, Ketil Heimdal, Per Mathisen, Mina Susanne Weedon-Fekjær, Solrun Sigurdardottir, Kristin Ørstavik, Birgitte Leisner Bjerkely |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Research Report
medicine.medical_specialty Visual analogue scale Endocrinology Diabetes and Metabolism Population QH426-470 Hospital Anxiety and Depression Scale Biochemistry Genetics and Molecular Biology (miscellaneous) Diseases of the endocrine glands. Clinical endocrinology Quality of life Internal Medicine Genetics Medicine pain Brief Pain Inventory education Depression (differential diagnoses) Disease burden education.field_of_study business.industry Research Reports medicine.disease RC648-665 Fabry disease humanities HRQOL Fabry depression Physical therapy fatigue business DS3 |
| Zdroj: | JIMD Reports JIMD Reports, Vol 62, Iss 1, Pp 56-69 (2021) |
| ISSN: | 2192-8312 2192-8304 |
| Popis: | Health‐related quality of life (HRQOL) is reduced in Fabry disease (FD) and associated with clinical disease manifestations, but few have used Fabry‐specific severity scores to study how disease burden interferes with quality of life. We investigated how the Fabry DS3, consisting of four somatic domains and one patient‐reported item, associates with HRQOL, while also evaluating fatigue, pain and psychological distress as possible predictors. Thirty‐six adults with FD completed the Short‐form Health Survey (SF‐36), the hospital anxiety and depression scale (HADS), the brief pain inventory (BPI) and reported fatigue on a visual analog scale. Clinical data were collected from the last multidisciplinary hospital visit. Using correlation and hierarchical linear regression analyses, we examined associations between demographic, clinical and self‐reported predictors and the SF‐36 physical (PCS) and mental (MCS) component summary scores. Males scored lower than the general population in all SF‐36 domains (P |
| Databáze: | OpenAIRE |
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