The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C

Autor:	Fernando Silva Neves, Adriana Dias Gomes, Rosângela Teixeira, Diego Alves Vieira, Gifone A. Rocha, Maria Thereza Bastos Almeida, Dulciene M.M. Queiroz, Luciana Diniz Silva, Luciana Rodrigues da Cunha, Cliviany Borges da Silva, César Lúcio Lopes de Faria, Fabrício Freire de Melo
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Genotype Single-nucleotide polymorphism 03 medical and health sciences Liver disease 0302 clinical medicine Quality of life Internal medicine Medicine Humans Mini-international neuropsychiatric interview business.industry Interleukin-6 030503 health policy & services Haplotype Public Health Environmental and Occupational Health Hepatitis C Chronic Middle Aged medicine.disease SNP genotyping Interleukin-10 Haplotypes 030220 oncology & carcinogenesis Quality of Life Major depressive disorder Female 0305 other medical science business
Zdroj:	Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 28(6)
ISSN:	1573-2649
Popis:	Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, − 819C/T, and − 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients. 132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations. Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36—physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype. This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03a62d191c3b3695690c93eca4975e6 https://pubmed.ncbi.nlm.nih.gov/30734130 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.