Craniomyeloschisis: A spontaneous mutation of the rat
| Autor: | W. M. Layton, J. M. Smith |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Embryology Axial skeleton Health Toxicology and Mutagenesis Breeding Biology Nervous System Malformations Toxicology Bone and Bones Autosomal recessive trait medicine Animals Abnormalities Multiple Urinary Tract Skull Neural tube Neural crest Anatomy Penetrance Pedigree Rats medicine.anatomical_structure Spinal Cord Mutation Mutation (genetic algorithm) Female Vertebral column Developmental Biology |
| Zdroj: | Teratology. 15:171-177 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420150207 |
| Popis: | Craniomyeloschisis (proposed gene symbol cms) was a spontaneous mutation of the rat inherited as an autosomal recessive trait with complete penetrance. Homozygous offspring died at birth with failure of closure of the neural tube caudal to the midbrain. Neural crest derivatives were relatively normal. There were associated severe malformations of the axial skeleton including skull, vertebral column, and ribs. The pattern of malformations was quite uniform. Heterozygotes were anatomically normal. The mutation is extinct. |
| Databáze: | OpenAIRE |
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