IGF-1 gene polymorphism in obese patients with insulin resistance

Autor: Fulya Akin, Raziye Kursunluoglu, S. Turgut, Guzin Fidan Yaylali
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
obesity
genomic DNA
medicine.medical_treatment
genotype
IGFBP3
somatomedin binding protein 3
Body Mass Index
Insulin-like growth factor
Polymorphism (computer science)
insulin resistance
Insulin-Like Growth Factor I
IGF-1 gene polymorphisim
anthropometry
thyroid function test
article
General Medicine
female
Female
Adult
medicine.medical_specialty
insulin
Biology
Insulin resistance
Internal medicine
Diabetes mellitus
Genetics
medicine
Humans
controlled study
Obesity
human
Molecular Biology
Body Weight/genetics
Case-Control Studies
Hormones/blood
Insulin Resistance/*genetics
Insulin-Like Growth Factor I/*genetics
Obesity/blood/*genetics
Polymorphism
Genetic
Insulin
Body Weight
medicine.disease
somatomedin C
major clinical study
Hormones
Endocrinology
DNA polymorphism
protein blood level
growth hormone
Gene polymorphism
Insulin Resistance
Popis: IGFs (Insulin like growth factors) are important regulators of pancreatic β cell development, growth and maintenance. Mutations in the IGF genes have been found to be associated with diabetes mellitus, myocardial infarction obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF-1 gene polymorphism in obese patients with insulin resistance. We included 100 obese patients with insulin resistance 30 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Thyroid function tests and serum IGFBP3 levels were similar between patients and controls whereas IGF, GH levels were significantly lower in obese patients. We categorized the IGF-1 (CA)19 polymorphism area into 3 groups as lower than 192 bp (group 1), 192-194 bp (group 2), and higher than 194 bp(group 3). Group 3 was more frequent in both obese and control groups. IGF-1 levels were also significantly lower in obese group (138.51 ± 49.3) in than controls (218.14 ± 69.15). IGF-1 levels were significantly lower in obese patients. The most frequent IGF-1 gen polymorphism allel is >194 bp in both obese insulin resistant patients and controls. IGF-1 levels and the other biochemical and hormonal parameters were similar in different genotype groups. The cause of lower IGF-1 levels in obese patients might be different from IGF-1 gene polymorphism and it may be insulin resistance. © 2009 Springer Science+Business Media B.V.
Databáze: OpenAIRE
Externí odkaz: