Cellular localisation of human epidermal growth factor receptor
| Autor: | Barry Gusterson, Gerard Cowley, John A. Smith, Bradford Ozanne |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Receptors Cell Surface Cell Biology Biology Monoclonal antibody Epithelium ErbB Receptors Immunoenzyme Techniques Molecular Weight Cell staining Endocrinology Cellular localisation Epidermal growth factor Internal medicine Neoplasms Cancer research medicine Immunohistochemistry Human epidermal growth factor receptor Distribution (pharmacology) Humans Receptor Cell Division |
| Zdroj: | Cell biology international reports. 8(8) |
| ISSN: | 0309-1651 |
| Popis: | We show here, using immunohistological techniques and a monoclonal antibody to the receptor for epidermal growth factor (EGFR) (Waterfield et al. 1982) that EGFR is present on a wide range of normal epithelial tissues and tumours arising from those sites. The distribution of the receptor suggests that EGF may be involved in the control of proliferation and possibly differentiation of surface epithelia. The strong tumour cell staining suggests an increased expression of the receptor in certain carcinomas. |
| Databáze: | OpenAIRE |
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