Characterization of mononuclear cell-derived histamine release enhancing factor
| Autor: | William R. Valenski, Robert L. Trouy, Lloyd V. Crawford, Henry G. Herrod, Robert E. Younger, Phillip Lieberman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Interleukin 2
Adult medicine.medical_treatment Immunology chemical and pharmacologic phenomena Basophil Peripheral blood mononuclear cell Histamine Release chemistry.chemical_compound medicine Biomarkers Tumor Immunology and Allergy Humans Phytohemagglutinins Cells Cultured Lymphokines Chemistry Tumor Protein Translationally-Controlled 1 In vitro Basophils Molecular Weight medicine.anatomical_structure Cytokine Biochemistry Leukocytes Mononuclear Liberation Arachidonic acid Histamine medicine.drug |
| Zdroj: | The Journal of allergy and clinical immunology. 80(4) |
| ISSN: | 0091-6749 |
| Popis: | Histamine release enhancing factor (HREF) is a product of phytohemagglutinin-stimulated mononuclear cells that substantially augments in vitro IgE-mediated basophil histamine release. The factor is stable at 56 degrees C and has a molecular weight in the 10,000 to 30,000 dalton range. The magnitude of HREF activity produced is dependent on the concentration of mononuclear cells cultured and the final concentration of HREF during basophil challenge. The HREF phenomenon could not be attributed to phytohemagglutinin, alpha- or gamma-interferon, arachidonic acid metabolites, or interleukin-1 or 2. HREF appears to be a unique cytokine of potential importance in the immunology of inflammatory and atopic processes. |
| Databáze: | OpenAIRE |
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