Nanoparticles: Oral Delivery for Protein and Peptide Drugs
| Autor: | Rui-dong Xia, Jiahua Dong, Shu-jun Cao, Xiang-hong Sun, Shuo Xu, Hui-ming Wang, Yong Ling |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Administration
Oral Pharmaceutical Science Nanoparticle Peptide Review Article 02 engineering and technology Absorption (skin) Aquatic Science Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Drug Discovery Humans Ecology Evolution Behavior and Systematics chemistry.chemical_classification Ecology Low toxicity Chemistry Proteins Chemical modification General Medicine 021001 nanoscience & nanotechnology oral delivery Bioavailability protein and peptide drugs Drug Design Nanoparticles Delivery system Nanocarriers Peptides bioavailability 0210 nano-technology Agronomy and Crop Science |
| Zdroj: | AAPS PharmSciTech |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-019-1325-z |
| Popis: | Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic. |
| Databáze: | OpenAIRE |
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