Evaluation of specific immunoglobulin A in nasal secretions and neutralizing antibodies in serum collected at multiple time points from young beef calves following intranasal or subcutaneous administration of a modified-live bovine respiratory syncytial virus vaccine
| Autor: | Emily J. Reppert, Amelia R. Woolums, Robert L. Weaber, Manuel F. Chamorro, Merrilee Thoresen, Shaun M. Huser, Natalia Cernicchiaro, Robert L. Larson, Heather N. Bornheim, Katherine Jones |
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| Rok vydání: | 2021 |
| Předmět: |
Immunoglobulin A
General Veterinary biology business.industry viruses Antibody titer Cattle Diseases Respiratory Syncytial Virus Bovine General Medicine Respiratory Syncytial Virus Infections Virology Antibodies Neutralizing Virus Respiratory Syncytial Virus Vaccines biology.protein Medicine Animals Nasal administration Cattle Respiratory system Antibody business |
| Zdroj: | American journal of veterinary research. 82(9) |
| ISSN: | 1943-5681 |
| Popis: | OBJECTIVE To determine anti-bovine respiratory syncytial virus (BRSV) antibody titers for nasal secretions and serum from beef calves following administration of a modified-live (MLV) BRSV vaccine. ANIMALS 60 healthy newborn purebred beef calves. PROCEDURES Calves were randomly assigned to 1 of 3 groups: intranasal (IN)-SC (IN MLV BRSV vaccine within 24 hours of birth and SC MLV BRSV vaccine at 2 months of age), SC-IN (SC MLV BRSV vaccine within 24 hours of birth and IN MLV BRSV vaccine at 2 months of age), or NO-IN (no vaccine within 24 hours of birth and IN MLV BRSV vaccine at 2 months of age). Nasal secretion and serum samples were collected for determination of anti-BRSV antibodies within 24 hours of birth and 2 and 6 months of age. RESULTS Titers of anti-BRSV IgA antibodies in nasal secretions and BRSV neutralizing antibodies in serum were similar among groups at each sampling time. Within 24 hours of birth, nasal anti-BRSV IgA titers were negligible. At 2 months, mean nasal anti-BRSV IgA titers for calves in IN-SC, SC-IN, and NO-IN groups were 192.84, 224.49, and 114.71, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Concentrations of anti-BRSV IgA antibodies in the nasal secretions and BRSV neutralizing antibodies in the serum of young beef calves following an MLV BRSV vaccine protocol that consisted of IN or SC vaccine within 24 hours of birth and vice versa at 2 months of age were not different from that following only an IN MLV BRSV vaccine at 2 months of age. However, the lack of any differences may have been attributed to other factors. (Am J Vet Res 2021;82:746–751) |
| Databáze: | OpenAIRE |
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