Rapid hydrolysis of amides under physiological conditions: influence of the microenvironment on the stability of the amide bond
| Autor: | Karl-Heinz Glüsenkamp, C. Mengede, W. Drosdziok, E. Jähde, Manfred F. Rajewsky |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Bicyclic molecule
Chemistry medicine.drug_class Hydrolysis Organic Chemistry Clinical Biochemistry Kinetics Pharmaceutical Science Carboxamide Prodrug Biochemistry Amides Structure-Activity Relationship Drug Discovery medicine Molecular Medicine Peptide bond Organic chemistry Amine gas treating Chemical stability Molecular Biology Half-Life |
| Zdroj: | Bioorganicmedicinal chemistry letters. 8(3) |
| ISSN: | 0960-894X |
| Popis: | A new class of bicyclic carboxyamides 1a-9a differing with respect to substitution patterns and exoendo geometry has been synthesized. These amides are characterized by a structure-dependent unusual rapid hydrolysis rate at physiological conditions. The corresponding bicyclic anhydrides might be used as tools for masking and modifiying therapeutic agents containing amine functionalities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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