Antidiabetic Properties of the Red Belt Conk Medicinal Mushroom Fomitopsis pinicola (Agaricomycetes) Extracts on Streptozotocin-Induced Diabetic Rats
Autor: | Iram Abdullah, Haiying Bao, Wei Ying, Muhammad Zahid, Asmaa Hussein Zaki, Muhammad Idrees |
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Rok vydání: | 2020 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Fomitopsis pinicola Diet High-Fat medicine.disease_cause Applied Microbiology and Biotechnology Antioxidants Streptozocin law.invention Rats Sprague-Dawley law Internal medicine Diabetes mellitus Drug Discovery Diabetes Mellitus medicine Animals Humans Hypoglycemic Agents Insulin Hypolipidemic Agents Pharmacology Kidney biology Plant Extracts Chemistry Streptozotocin medicine.disease biology.organism_classification Rats Metformin Cholesterol medicine.anatomical_structure Endocrinology Liver Hyperglycemia Coriolaceae Phytotherapy Oxidative stress medicine.drug |
Zdroj: | International Journal of Medicinal Mushrooms. 22:731-741 |
ISSN: | 1521-9437 |
Popis: | The antidiabetic effect of different doses of water extract (WE) and ethanol extract (EE) was tested on a high-fat diet and streptozotocin (STZ) induced diabetic rats. Parameters were evaluated with normal control (NC), diabetes mellitus control (DM), and metformin (M) groups. In the experiment, nine groups were used with eight rats in each group and three doses of each WE and EE were used, with low, medium, and high doses. The results revealed that the DM group lost a significant amount of weight, whereas the NC group's weight increased throughout the experiment. After treatment with Fomitopsis pinicola, the EE group's weight increased gradually. Liver, kidney, and pancreas weight decreased after STZ injection and returned to normal in EE treated groups. Fasting blood glucose (FBG) levels were observed to be significantly lower after F. pinicola treatment. Serum insulin levels were also restored to normal after mushroom extracts supplementation. Specifically, STZ-induced hyperglycemia was inhibited by high dose EE administration. The biochemical analysis revealed that high-dose EE treatment increased HDL-C and decreased TC, TG, and LDL-C. Results demonstrated that high-dose EE administration protected the organ tissues from oxidative stress by normalizing the antioxidant levels, and CAT, SOD, and GSH-Px suppressed the lethal effect of MDA. The study concluded that F. pinicola EE at the dose 300 mg/kg has a more hypoglycemic, hyperinsulinemic, antioxidant, and antihyperlipidemic effect than NC, DM, and M, and regulates hyperglycemia by increasing insulin secretion. |
Databáze: | OpenAIRE |
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