Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives
| Autor: | Jon D. Lippiat, Hayley Pearson, Jamel Mankouri, John N. Barr, Samantha Hover, Juan Fontana, Frank W. Charlton |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:QR1-502 virus–host interactions Disease Review virus Biology Virus Replication Antiviral Agents Ion Channels Sodium Channels lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine antivirals Chloride Channels Virology Animals Humans Ion channel Drug Repositioning Virus Internalization channelopathies Drug repositioning 030104 developmental biology Infectious Diseases Virus Diseases ion channel Calcium Channels Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Viruses, Vol 12, Iss 844, p 844 (2020) Viruses |
| ISSN: | 1999-4915 |
| Popis: | Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of which are in widespread human usage for ion channel-related diseases, highlighting new potential for drug repurposing. The emergence of ion channel–virus interactions has also revealed the intriguing possibility that channelopathies may explain some commonly observed virus induced pathologies. This field is rapidly evolving and an up-to-date summary of new discoveries can inform future perspectives. We herein discuss the role of ion channels during viral lifecycles, describe the recently identified ion channel drugs that can inhibit viral infections, and highlight the potential contribution of ion channels to virus-mediated disease. |
| Databáze: | OpenAIRE |
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