Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats
| Autor: | Richard D Wainford, Alissa A. Frame, Jill T. Kuwabara, J. Thomas Cunningham, Casey Y. Carmichael |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Physiology Natriuresis 030204 cardiovascular system & hematology Kidney afferent renal nerves Rats Sprague-Dawley 03 medical and health sciences Norepinephrine 0302 clinical medicine sodium homeostasis Physiology (medical) Internal medicine medicine Animals Homeostasis Sodium Chloride Dietary Renal Afferent Pathways Nutrition and Dietetics Rats Inbred Dahl business.industry Sodium blood pressure General Medicine Research Papers Hypertonic saline Rats Endocrinology Blood pressure Hypothalamus Hypertension Reflex Mechanosensitive channels business 030217 neurology & neurosurgery Ex vivo Research Paper Paraventricular Hypothalamic Nucleus |
| Zdroj: | Experimental Physiology |
| ISSN: | 1469-445X 0958-0670 |
| Popis: | NEW FINDINGS What is the central question of this study? What are the differential roles of the mechanosensitive and chemosensitive afferent renal nerves in the reno-renal reflex that promotes natriuresis, sympathoinhibition and normotension during acute and chronic challenges to sodium homeostasis? What is the main finding and its importance? The mechanosensitive afferent renal nerves contribute to an acute natriuretic sympathoinhibitory reno-renal reflex that may be integrated within the paraventricular nucleus of the hypothalamus. Critically, the afferent renal nerves are required for the maintenance of salt resistance in Sprague-Dawley and Dahl salt-resistant rats and attenuate the development of Dahl salt-sensitive hypertension. ABSTRACT These studies tested the hypothesis that in normotensive salt-resistant rat phenotypes the mechanosensitive afferent renal nerve (ARN) reno-renal reflex promotes natriuresis, sympathoinhibition and normotension during acute and chronic challenges to fluid and electrolyte homeostasis. Selective ARN ablation was conducted prior to (1) an acute isotonic volume expansion (VE) or 1 m NaCl infusion in Sprague-Dawley (SD) rats and (2) chronic high salt intake in SD, Dahl salt-resistant (DSR), and Dahl salt-sensitive (DSS) rats. ARN responsiveness following high salt intake was assessed ex vivo in response to noradrenaline and sodium concentration (SD, DSR and DSS) and via in vivo manipulation of renal pelvic pressure and sodium concentration (SD and DSS). ARN ablation attenuated the natriuretic and sympathoinhibitory responses to an acute VE [peak natriuresis (µeq min-1 ) sham 52 ± 5 vs. ARN ablation 28 ± 3, P |
| Databáze: | OpenAIRE |
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