Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation

Autor: Eduardo López-Larraz, Marlieke Scholten, Daniel Weiss, Alireza Gharabaghi, Ander Ramos-Murguialday, Anna Schoellmann
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
therapy [Parkinson Disease]
Parkinson's disease
Deep Brain Stimulation
Movement
Audiology
Electroencephalography
050105 experimental psychology
physiology [Psychomotor Performance]
Functional Laterality
Fingers
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
physiology [Cortical Synchronization]
physiology [Movement]
Modulation (music)
medicine
Humans
0501 psychology and cognitive sciences
ddc:610
Cortical Synchronization
Aged
Physics
medicine.diagnostic_test
05 social sciences
physiology [Functional Laterality]
Motor Cortex
physiopathology [Motor Cortex]
Parkinson Disease
Neurophysiology
physiopathology [Fingers]
Middle Aged
medicine.disease
Phase synchronization
Sensory Systems
Electrophysiology
Neurology
Finger tapping
Tapping
Female
Neurology (clinical)
physiopathology [Parkinson Disease]
030217 neurology & neurosurgery
Psychomotor Performance
Zdroj: Clinical neurophysiology 131(10), 2499-2507 (2020). doi:10.1016/j.clinph.2020.05.037
ISSN: 1872-8952
DOI: 10.1016/j.clinph.2020.05.037
Popis: Objective Freezing phenomena in idiopathic Parkinson’s disease (PD) constitute an important unaddressed therapeutic need. Changes in cortical neurophysiological signatures may precede a single freezing episode and indicate the evolution of abnormal motor network processes. Here, we hypothesize that the movement-related power modulation in the beta-band observed during regular finger tapping, deteriorates in the transition period before upper limb freezing (ULF). Methods We analyzed a 36-channel EEG of 13 patients with PD during self-paced repetitive tapping of the right index finger. In offline analysis, we compared the transition period immediately before ULF (‘transition’) with regular tapping regarding movement-related power modulation and interregional phase synchronization. Results From time-frequency analyses, we observed that the tap cycle related beta-band power modulation over the left sensorimotor area was diminished in the transition period before ULF. Furthermore, increased beta-band power was observed in the transition period compared to regular tapping centered over the left centro-parietal and right frontal areas. Phase synchronization between the left fronto-parietal areas and the left sensorimotor area was elevated during transition compared to regular tapping. Conclusion Together, these results indicate that diminished beta band power modulation and increased phase synchronization precede ULF. Significance We demonstrate that pathological cortical motor processing is present in the transition phase from regular tapping to an ULF episode.
Databáze: OpenAIRE
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