Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
| Autor: | Elvita Caputo, Maria Serra, Anna Presicci, Lucia Margari, Mariaclara Achille |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Systemic disease neuromyelitis optica Case Report acquired demyelinating syndromes Context (language use) myelin oligodendrocyte glycoprotein multiple sclerosis RJ1-570 Myelin oligodendrocyte glycoprotein pediatric optic neuritis Medicine Optic neuritis Demyelinating Disorder Neuromyelitis optica biology business.industry Multiple sclerosis medicine.disease Pediatrics Perinatology and Child Health Etiology biology.protein ADEM-ON business |
| Zdroj: | Children, Vol 8, Iss 855, p 855 (2021) Children |
| ISSN: | 2227-9067 |
| DOI: | 10.3390/children8100855 |
| Popis: | Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options. |
| Databáze: | OpenAIRE |
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