Could platelet to leucocytic count ratio (PLR) predict sepsis and clinical outcomes in patients with emphysematous pyelonephritis?
| Autor: | Mohamad H. Zahran, Mohamed Badawy, Mohamed Abdelbaset Ibrahim, M.A. Elbaset, Eman Elrefaie, Abdelwahab Hashem, Fady K. Ghobrial, Ahmed A. Shokeir |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Multivariate analysis 030106 microbiology Kidney Gastroenterology Sepsis Leukocyte Count 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus Humans Medicine Pharmacology (medical) Hospital Mortality 030212 general & internal medicine Kidney infection Hydronephrosis Retrospective Studies Emphysema Creatinine Univariate analysis Pyelonephritis Platelet Count business.industry Middle Aged Prognosis medicine.disease Shock Septic body regions Infectious Diseases chemistry Female business Body mass index |
| Zdroj: | Journal of Infection and Chemotherapy. 25:791-796 |
| ISSN: | 1341-321X |
| Popis: | Objectives To study risk factors for sepsis and mortality evaluating the role of platelet to leucocytic count ratio (PLR) as a marker for urosepsis and clinical outcomes in cases of emphysematous pyelonephritis (EPN). Materials Patients with EPN were retrospectively reviewed. Patients' age, sex, diabetes mellitus (DM), Body Mass Index (BMI), hydronephrosis, types of EPN, air locules volume, serum creatinine, leucocytic count, and platelet count, PLR, albumin, INR and the line of treatment were analyzed as risk factors of sepsis. Correlation between PLR and other variables was done using Pearson correlation coefficient. Univariate and multivariate analyses for sepsis and mortality were performed. Results Of fifty four patients, 38 patients had SIRS ≥2 criteria on admission. Twenty patients developed sepsis requiring ICU admission. In univariate analysis, male gender, lower BMI, higher INR, higher WBCs count and lower PLR were associated with sepsis (P = 0.0001, 0.009, 0.04, 0.003 and 0.001, respectively). In multivariate analysis, PLR ≤18.4, male sex and BMI ≤24.2 were independent risk factors. Lower PLR directly correlated with serum albumin (P = 0.01) and inversely correlated with serum creatinine and random blood glucose level and Klebsiella infection (P = 0.001, 0.007 and 0.005, respectively). Also, it was correlated with a higher total score of qSOFA and SOFA (P = 0.02 and 0.04). Lower PLR was independent risk factors for death in EPN patients with (P = 0.003). Conclusion EPN is associated with sepsis development. Lower PLR is an independent simple predictor for sepsis and mortality in patients with EPN. |
| Databáze: | OpenAIRE |
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