| Autor: |
Tuncay Alan, Ninnuja Sivanantha, Muhsincan Sesen, David J. Collins, Jason Brenker, Adrian Neild, Charles Wai Chung Ma, Ross L. Coppel |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Physics Procedia. :18-20 |
| ISSN: |
1875-3892 |
| DOI: |
10.1016/j.phpro.2015.08.016 |
| Popis: |
A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μ L droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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