The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
| Autor: | Iha Park, Jiyoung Park, Jong Suk Kim, Ying Zhang, Hyun Ae Woo, Seung-Rock Lee, Seong Jeong Han, Thang Nguyen Huu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Peroxiredoxin III medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Physiology (medical) medicine Humans PTEN Protein kinase B chemistry.chemical_classification Reactive oxygen species biology Lipogenesis Fatty liver PTEN Phosphohydrolase medicine.disease Cell biology 030104 developmental biology Liver chemistry biology.protein Alcoholic fatty liver Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress Fatty Liver Alcoholic |
| Zdroj: | Free Radical Biology and Medicine. 162:141-148 |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/j.freeradbiomed.2020.11.022 |
| Popis: | Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPARγ. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD. |
| Databáze: | OpenAIRE |
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