ESP-102, a Combined Herbal Extract ofAngelica gigas,Saururus chinensis, andSchisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

Autor: SangSeong Kim, Young-Choong Kim, Ji Ho Park, Seok Lee, Cheol-Won Lee, Hyun Bum Kim, Tae-Suk Park, Ga-Young Choi, Eun-Sang Hwang, Eun-Suk Lee, S.-H. Lee
Rok vydání: 2016
Předmět:
Zdroj: Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2016 (2016)
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2016/8793095
Popis: ESP-102, an extract fromAngelica gigas, Saururus chinensis, andSchisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivitiesin vitroandin vivostudies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.
Databáze: OpenAIRE
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