Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy
| Autor: | Claire W. Hallahan, Anthony S. Fauci, Colin Kovacs, J. Shawn Justement, Tae-Wook Chun, Susan Moir, Danielle Murray |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Anti-HIV Agents T cell HIV Infections Viremia Biology Residual Major Articles and Brief Reports Plasma Proviruses Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Immunopathology medicine Humans Immunology and Allergy Sida Aged HIV virus diseases Middle Aged Provirus medicine.disease biology.organism_classification Virology Infectious Diseases medicine.anatomical_structure DNA Viral Immunology Female Viral disease |
| Zdroj: | The Journal of Infectious Diseases. 204:135-138 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jir208 |
| Popis: | Residual plasma viremia (50 copies/mL) persists in certain human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4(+) T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication. |
| Databáze: | OpenAIRE |
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