Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators
| Autor: | C. R. B. Welbourn, Y. Young |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Inflammation
Respiratory Distress Syndrome Lipopolysaccharide business.industry Septic shock Neutrophils Lung injury medicine.disease Pulmonary edema Shock Septic Systemic inflammatory response syndrome Endotoxins chemistry.chemical_compound chemistry Shock (circulatory) Immunology Medicine Humans Surgery medicine.symptom business Multiple organ dysfunction syndrome |
| Zdroj: | The British journal of surgery. 79(10) |
| ISSN: | 0007-1323 |
| Popis: | The treatment of septic shock remains a major problem in surgical practice. Current research on the pathogenesis of the sepsis syndrome focuses on the effects of the lipopolysaccharide constituents of bacterial endotoxin. Evidence suggests that endotoxin induces a whole-body inflammatory response that in turn mediates organ damage, eventually leading to multiorgan failure. The first organ in which failure is usually apparent is the lung, with the appearance of nonEndotoxin, septic shock and acute lung injury:-cardiogenic pulmonary oedema as part of the adult respiratory distress syndrome. Inflammatory cells involved in lung injury include neutrophils and macrophages, which release mediators such as elastase, oxygen radicals and cytokines. This review summarizes current experimental work on how endotoxin leads to lung injury, based on its effects in animals and patients. Present knowledge suggests that future treatment of septic shock might involve inhibiting the body's inflammatory response to endotoxin. Possible ways of doing this are discussed. |
| Databáze: | OpenAIRE |
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