Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice

Autor: Michael Müller, Aswin L. Menke, Wilma T. Steegenga, Fenni Rusli, Miriam van Dijk, Carolien Lute, Mark V. Boekschoten, Klaske van Norren
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Aging
Moderate-fat diet
Mice
Voeding
Metabolisme en Genomica
Adverse health effect
Insulin
Research Articles
Human Nutrition & Health
2. Zero hunger
Principal Component Analysis
Humane Voeding & Gezondheid
Metabolism and Genomics
Nutritional Biology
3. Good health
Intermittent calorie restriction
Liver
Metabolisme en Genomica
Body Composition
Cytokines
Nutrition
Metabolism and Genomics
Research Article
Biotechnology
Moderate‐fat diet
medicine.medical_specialty
Diet switch
Calorie restriction
Biology
C57bl 6j
03 medical and health sciences
Voeding
Internal medicine
medicine
Animals
Obesity
Transcriptomics
Adverse effect
Beneficial effects
Triglycerides
Nutrition
Caloric Restriction
VLAG
Body Weight
Computational Biology
medicine.disease
Dietary Fats
Diet
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Fat diet
Food Science
Zdroj: Molecular Nutrition & Food Research 61 (2017) 5
Molecular Nutrition & Food Research, 61(5)
Molecular Nutrition & Food Research
ISSN: 1613-4125
Popis: Scope: Calorie restriction (CR) has been shown to extend life- and health-span in model species. For most humans, a life-long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can (1) provide long-term beneficial effects and (2) counteract diet-induced obesity in male aging mice. Methods and results: In this study, we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate-fat (MF) feeding. This weekly intermittent CR significantly counteracted the adverse effects of the MF diet on mortality, body weight, and liver health markers in 24-month-old male mice. Hepatic gene expression profiles of INT-exposed animals appeared much more comparable to CR- than to MF-exposed mice. At 12 months of age, a subgroup of MF-exposed mice was transferred to the INT diet. Gene expression profiles in the liver of the 24-month-old diet switch mice were highly similar to the INT-exposed mice. However, a small subset of genes was consistently changed by the MF diet during the first phase of life. Conclusion: Weekly intermittent CR largely, but not completely, reversed adverse effects caused by a MF diet.
Databáze: OpenAIRE
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