Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit

Autor: N. Le Roy, Lilian Stapane, Joël Gautron, Alejandro B. Rodríguez-Navarro, Yves Nys, Maxwell T. Hincke
Přispěvatelé: Biologie des Oiseaux et Aviculture (BOA), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidad de Granada (UGR), University of Ottawa [Ottawa], SERC (RGPIN-2016-04410), Agreenskills, University of Tours, Région Centre, ANR-13-BSV1-0007,TMEM33,TMEM33 et polykystose rénale(2013), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-17 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, BioMed Central, 2021, 22 (1), ⟨10.1186/s12860-021-00350-0⟩
Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 2661-8850
Popis: The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds of proteins that interact with the mineral phase controlling its formation and structural organization, and thus determine the mechanical properties of the mature biomaterial. We describe its mineralogy, structure and the regulatory interactions that integrate the mineral and organic constituents. We underline recent evidence for vesicular transfer of amorphous calcium carbonate (ACC), as a new pathway to ensure the active and continuous supply of the ions necessary for shell mineralization. Currently more than 900 proteins and thousands of upregulated transcripts have been identified during chicken eggshell formation. Bioinformatic predictions address their functionality during the biomineralization process. In addition, we describe matrix protein quantification to understand their role during the key spatially- and temporally- regulated events of shell mineralization. Finally, we propose an updated scheme with a global scenario encompassing the mechanisms of avian eggshell mineralization. With this large dataset at hand, it should now be possible to determine specific motifs, domains or proteins and peptide sequences that perform a critical function during avian eggshell biomineralization. The integration of this insight with genomic data (nonsynonymous single nucleotide polymorphisms) and precise phenotyping (shell biomechanical parameters) on pure selected lines will lead to consistently better-quality eggshell characteristics for improved food safety. This information will also address the question of how the evolutionary-optimized chicken eggshell matrix proteins affect and regulate calcium carbonate mineralization as a good example of biomimetic and bio-inspired material design.
French National Research Agency (ANR) European Commission ANR-13-BSV-0007-01
Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2016-04410
Le STUDIUM
Centre Val de Loire, Nouzilly, France - University of Tours
Databáze: OpenAIRE
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