Predominant synthesis of giant myofibrillar proteins in striated muscles of the long-tailed ground squirrel Urocitellus undulatus during interbout arousal

Autor:	Svetlana Popova, Alexander Bobylev, Oleg S. Morenkov, Yulia Gritsyna, Ivan M. Vikhlyantsev, Nadezda Zakharova, A. D. Ulanova, Vadim Rogachevsky, Yana Yutskevich, G. Z. Mikhailova, N. N. Salmov, L. G. Bobyleva
Rok vydání:	2020
Předmět:	0301 basic medicine Hibernation medicine.medical_specialty Histology lcsh:Medicine Muscle Proteins Biology Striated Muscles Biochemical assays Article Arousal 03 medical and health sciences Nebulin Myofibrils Internal medicine Electron microscopy medicine Animals Connectin lcsh:Science Ground squirrel Cytoskeleton Multidisciplinary 030102 biochemistry & molecular biology Hyperactivation Calpain Myocardium lcsh:R Body Weight Sciuridae Proteases musculoskeletal system biology.organism_classification Muscle Striated Cytoskeletal proteins 030104 developmental biology Endocrinology Proteolysis biology.protein lcsh:Q Titin Seasons Myofibril
Zdroj:	Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
ISSN:	2045-2322
DOI:	10.1038/s41598-020-72127-y
Popis:	Molecular mechanisms underlying muscle-mass retention during hibernation have been extensively discussed in recent years. This work tested the assumption that protein synthesis hyperactivation during interbout arousal of the long-tailed ground squirrel Urocitellus undulatus should be accompanied by increased calpain-1 activity in striated muscles. Calpain-1 is known to be autolysed and activated in parallel. Western blotting detected increased amounts of autolysed calpain-1 fragments in the heart (1.54-fold, p p p p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d022d79e6c8682814feaff2bf876944c https://doi.org/10.1038/s41598-020-72127-y Zobrazit plný text záznamu