Bone turnover markers in HIV-infected women on tenofovir-based antiretroviral therapy
| Autor: | Malie Rheeders, Iolanthé M. Kruger, Mwila Mulubwa, Michelle Viljoen, Herculina S. Kruger |
|---|---|
| Přispěvatelé: | 12079642 - Kruger, Iolanthé Marike, 10061568 - Kruger, Herculina Salome, 10064117 - Rheeders, Malie, 10215344 - Viljoen, Michelle, 24270148 - Mulubwa, Mwila |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty chemistry.chemical_element Parathyroid hormone Calcium Bone remodeling 03 medical and health sciences 0302 clinical medicine Female HIV-infected N-terminal telopeptide Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine Bone mineral business.industry lcsh:Public aspects of medicine Tenofovir levels lcsh:RA1-1270 030112 virology Antiretroviral therapy Infectious Diseases Endocrinology chemistry Alkaline phosphatase business Bone turnover markers |
| Zdroj: | Southern African Journal of HIV Medicine, Vol 18, Iss 1, Pp e1-e7 (2017) |
| Popis: | Background: Tenofovir disoproxil fumarate (TDF) antiretroviral therapy is associated with disruption of the bone turnover process.Objectives: The objective of this study was to determine the association between tenofovir (TFV) plasma concentration and various bone turnover markers and compare these markers in HIV-infected women and HIV-uninfected controls.Method: A cross-sectional sub-study included 30 HIV-infected women on TDF and 30 HIV-uninfected matched participants. Serum calcium (SrCa), serum phosphate (SrP), C-terminal telopeptide (CTx), parathyroid hormone (PTH), alkaline phosphatase (ALP), C-reactive protein (CRP), vitamin D (VitD) and bone mineral density (BMD) were measured. Plasma TFV was assayed on HPLC-MS/MS. The statistical tests applied were Mann–Whitney test, unpaired t-test, analysis of covariance, regression and correlation analysis.Results: In HIV-infected women, no correlation existed between plasma TFV concentration and CTx, PTH, ALP, SrCa, SrP, VitD or BMD (p > 0.05). After adjusting for smoking and alcohol use, ALP (p < 0.001), CTx (p = 0.027) and PTH (p = 0.050) were significantly higher in HIV-infected compared to HIV-uninfected women. Women with TFV concentration ≥ 120 ng/mL had higher PTH concentrations (p = 0.037) compared to those with ≤ 100 ng/mL. Significant correlations between SrCa and PTH and SrCa and SrP including CTx and PTH (p < 0.05) were present in HIV-uninfected women while absent in HIV-infected counterparts (p > 0.05).Conclusion: The results indicate possible increased bone turnover at higher TFV concentrations. The normal regular bone turnover processes in HIV-infected women on TDF therapy are altered. Larger studies are warranted to confirm these results. |
| Databáze: | OpenAIRE |
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