Increased susceptibility to staphylococcal enterotoxin B intoxication in mice primed with actinomycin D
| Autor: | Wallace B. Baze, I. C. Hsu, Jeenan Tseng, Y. Qiao, J L Komisar, J. Y J Chen |
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| Rok vydání: | 1994 |
| Předmět: |
Staphylococcus aureus
Lipopolysaccharide Immunology chemical and pharmacologic phenomena Spleen Inflammation Enterotoxin Biology Microbiology Enterotoxins Mice chemistry.chemical_compound Intestine Small medicine Animals Lung Mice Inbred BALB C Mice Inbred C3H Dactinomycin Toxic shock syndrome Haplorhini medicine.disease Small intestine Infectious Diseases medicine.anatomical_structure chemistry Toxicity Parasitology medicine.symptom Research Article medicine.drug |
| Zdroj: | Infection and Immunity. 62:4626-4631 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.62.10.4626-4631.1994 |
| Popis: | Mice (BALB/cJ, C3H/HeN, and C3H/HeJ) primed with actinomycin D became highly susceptible to lethal intoxication with staphylococcal enterotoxin B (SEB). The mice underwent toxicosis and toxic shock and died. Actinomycin D-primed C3H/HeN and C3H/HeJ mice showed equal sensitivity to SEB, suggesting that bacterial lipopolysaccharide derived from gram-negative bacteria in the gut may not be an important cofactor in intoxication. In a time course study of the illness, prominent pathological changes characterized by blood congestion and thickening of alveolar septa were seen in the lung, while blood congestion, inflammation, epithelial cell flattening, and villous blunting were seen in the small intestine. In lymphoid tissues, such as the spleen, congestion, inflammation, and lymphoid cell depletion were the major reactions. The pathological features of the mice had many similarities to those of rhesus monkeys intoxicated with intravenous SEB. The actinomycin D-primed C3H/HeJ mice are thus an ideal mouse model for studying SEB toxicosis and toxic shock. |
| Databáze: | OpenAIRE |
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