Clinical features of dementia cases ascertained by ICD coding in LIMBIC-CENC multicenter study of mild traumatic brain injury

Autor: William C. Walker, Justin O’Rourke, Elisabeth Anne Wilde, Mary Jo Pugh, Kimbra Kenney, Clara Libby Dismuke-Greer, Zhining Ou, Angela P. Presson, J. Kent Werner, Jacob Kean, Deborah Barnes, Amol Karmarkar, Kristine Yaffe, David Cifu
Rok vydání: 2022
Předmět:
cognition
Physical Injury - Accidents and Adverse Effects
Neuroscience (miscellaneous)
veteran
Traumatic Brain Injury (TBI)
2003-2011
Medical and Health Sciences
Article
Stress Disorders
Post-Traumatic
Iraq War
Traumatic brain injury
Blast Injuries
International Classification of Diseases
Clinical Research
Behavioral and Social Science
Developmental and Educational Psychology
Acquired Cognitive Impairment
Humans
2.1 Biological and endogenous factors
Longitudinal Studies
Prospective Studies
Aetiology
Iraq War
2003-2011
Brain Concussion
military
Traumatic Head and Spine Injury
Stress Disorders
Aged
Veterans
Afghan Campaign 2001
Psychology and Cognitive Sciences
Rehabilitation
Neurosciences
Post-Traumatic Stress Disorder (PTSD)
Brain Disorders
Cross-Sectional Studies
Mental Health
Neurological
Post-Traumatic
concussion
Dementia
Neurology (clinical)
Zdroj: Brain injury, vol 36, iss 5
Brain Inj
Popis: OBJECTIVE: Describe dementia cases identified through International Classification of Diseases (ICD) coding in the Long-term Impact of Military-relevant Brain Injury Consortium – Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter prospective longitudinal study (PLS) of mild traumatic brain injury (mTBI). DESIGN: Descriptive case series using cross-sectional data. METHODS: Veterans Affairs (VA) health system data including ICD codes were obtained for 1563 PLS participants through the VA Informatics and Computing Infrastructure (VINCI). Demographic, injury, and clinical characteristics of Dementia positive and negative cases are described. RESULTS: Five cases of dementia were identified, all under 65 years old. The dementia cases all had a history of blast-related mTBI and all had self-reported functional problems and four had PTSD symptomatology at the clinical disorder range. Cognitive testing revealed some deficits especially in the visual memory and verbal learning and memory domains, and that two of the cases might be false positives. CONCLUSIONS: ICD codes for early dementia in the VA system have specificity concerns, but could be indicative of cognitive performance and self-reported cognitive function. Further research is needed to better determine links to blast exposure, blast-related mTBI, and PTSD to early dementia in the military population.
Databáze: OpenAIRE
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