Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
| Autor: | Imtiaz Ahmad Qureshi, Jaudah Al-Maghrabi, Mohamad Nidal Khabaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
urologic and male genital diseases Gastroenterology leptin Bladder Neoplasm Internal medicine medicine Carcinoma Humans Urothelium Lymph node urinary bladder cancer Bladder cancer Tissue microarray business.industry Leptin General Medicine medicine.disease Prognosis female genital diseases and pregnancy complications medicine.anatomical_structure Urinary Bladder Neoplasms immunohistochemistry Immunohistochemistry Medicine Original Article business Research Article |
| Zdroj: | Libyan Journal of Medicine, Vol 16, Iss 1 (2021) The Libyan Journal of Medicine article-version (VoR) Version of Record Libyan Journal of Medicine; Vol. 16 No. 1 (2021) |
| ISSN: | 1819-6357 1993-2820 |
| Popis: | This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies. A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays. Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03). These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma. |
| Databáze: | OpenAIRE |
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