GC/MS Analysis of m -Hydroxybenzoylecgonine in Urine: Forensic Implication in Cocaine Use
| Autor: | Wlodzimierz J. Kopycki, Mahmoud A. ElSohly, Timothy P. Murphy, Shixia Feng, Brian J. Lukey |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Chromatography
Chemistry Metabolite Biochemistry (medical) Clinical Biochemistry Public Health Environmental and Occupational Health Urine humanities Pathology and Forensic Medicine Psychiatry and Mental health chemistry.chemical_compound M-Hydroxybenzoylecgonine Genetics Cocaine use Gas chromatography–mass spectrometry |
| Zdroj: | Clinics in Laboratory Medicine. 18:699-704 |
| ISSN: | 0272-2712 |
| DOI: | 10.1016/s0272-2712(18)30145-8 |
| Popis: | m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m-hydroxybenzoylecgonine (d3-m-OH-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as internal standard has been developed. Among 24 human urine specimens that were positive for BE, all of them have shown detectable levels of m-OH-BE with 75% of the specimens exceeding the LoQ (5 ng/mL), compared with only 50% of the specimens containing detectable levels of EME. The presence of m-OH-BE in urine suggested that this metabolite may serve as a valuable marker of cocaine use in addition to BE and EME. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|