Increased risk for severe malaria in HIV-1-infected adults, Zambia
| Autor: | Chalwe, Joris Menten, Modest Mulenga, Mukwamataba D, Kamalamba J, Umberto D'Alessandro, Van geertruyden Jp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Epidemiology Population lcsh:Medicine Zambia Viral diseases Asymptomatic Africa Southern lcsh:Infectious and parasitic diseases Internal medicine parasitic diseases Medicine lcsh:RC109-216 Young adult education HIV/AIDS and other retroviruses education.field_of_study biology Co-infections business.industry Severe infection lcsh:R Case-control study CD4 lymphocyte count Plasmodium falciparum Odds ratio opportunistic infections Protozoal diseases medicine.disease biology.organism_classification Malaria AIDS Infectious Diseases Risk factors Africa Immunology HIV-1 Human medicine medicine.symptom business Immunosuppression |
| Zdroj: | Emerging infectious diseases Emerging Infectious Diseases, Vol 15, Iss 5, Pp 749-755 (2009) |
| ISSN: | 1080-6040 |
| DOI: | 10.3201/eid1505.081009 |
| Popis: | To determine whether HIV-1 infection and HIV-1-related immunosuppression were risk factors for severe malaria in adults with some immunity to malaria, we conducted a case-control study in Luanshya, Zambia, during December 2005-March 2007. For each case-patient with severe malaria, we selected 2 matched controls (an adult with uncomplicated malaria and an adult without signs of disease). HIV-1 infection was present in 93% of case-patients, in 52% of controls with uncomplicated malaria, and in 45% of asymptomatic controls. HIV-1 infection was a highly significant risk factor for adults with severe malaria compared with controls with uncomplicated malaria (odds ratio [OR] 12.6, 95% confidence interval [CI] 2.0-78.8, p = 0.0005) and asymptomatic controls (OR 16.6, 95% CI 2.5-111.5, p = 0.0005). Persons with severe malaria were more likely to have a CD4 count |
| Databáze: | OpenAIRE |
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