FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
| Autor: | Hui Hu, Daria Neyroud, Chandler S. Callaway, Andrew Judge, Sarah M. Judge, Rachel L. Nosacka, Jose G. Trevino |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cachexia Diseases of the musculoskeletal system Mice 03 medical and health sciences 0302 clinical medicine Atrophy Muscle regeneration Physiology (medical) Internal medicine medicine Animals Humans Orthopedics and Sports Medicine Muscle Skeletal Myopathy Wasting Actin business.industry QM1-695 Skeletal muscle Muscle weakness Cancer cachexia Forkhead Transcription Factors Original Articles Pancreatic cancer medicine.disease Muscle atrophy 3. Good health Repressor Proteins Muscular Atrophy 030104 developmental biology medicine.anatomical_structure Endocrinology RC925-935 030220 oncology & carcinogenesis Human anatomy Colonic Neoplasms Original Article medicine.symptom business |
| Zdroj: | Journal of Cachexia, Sarcopenia and Muscle Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 2, Pp 421-442 (2021) |
| ISSN: | 2190-6009 2190-5991 |
| Popis: | Background Skeletal muscle wasting is a devastating consequence of cancer that affects up to 80% of cancer patients and associates with reduced survival. Herein, we investigated the biological significance of Forkhead box P1 (FoxP1), a transcriptional repressor that we demonstrate is up‐regulated in skeletal muscle in multiple models of cancer cachexia and in cachectic cancer patients. Methods Inducible, skeletal muscle‐specific FoxP1 over‐expressing (FoxP1iSkmTg/Tg) mice were generated through crossing conditional Foxp1a transgenic mice with HSA‐MCM mice that express tamoxifen‐inducible Cre recombinase under control of the skeletal muscle actin promoter. To determine the requirement of FoxP1 for cancer‐induced skeletal muscle wasting, FoxP1‐shRNA was packaged and targeted to muscles using AAV9 delivery prior to inoculation of mice with Colon‐26 Adenocarcinoma (C26) cells. Results Up‐regulation of FoxP1 in adult skeletal muscle was sufficient to induce features of cachexia, including 15% reduction in body mass (P |
| Databáze: | OpenAIRE |
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