Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast, and Head and Neck Cancer Treatment: Current Status of Research
| Autor: | Alessandra Coppola, Francesca Vitiello, Martina Pagano, Laura Mosca, Luigi Borzacchiello, Giovanna Cacciapuoti, Concetta Paola Ilisso, Michele Caraglia, Marina Porcelli |
|---|---|
| Přispěvatelé: | Mosca, L., Vitiello, F., Coppola, A., Borzacchiello, L., Ilisso, C. P., Pagano, M., Caraglia, M., Cacciapuoti, G., Porcelli, M. |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer therapy Combination therapy Breast Neoplasms Context (language use) Review Natural compound Phytochemical Synergistic interaction Catalysis Metastasis lcsh:Chemistry Inorganic Chemistry Breast cancer Antineoplastic Combined Chemotherapy Protocols natural compounds Humans Medicine Doxorubicin Neoplasm Metastasis Physical and Theoretical Chemistry Head and neck cancer lcsh:QH301-705.5 Molecular Biology Spectroscopy S-adenosylmethionine Squamous Cell Carcinoma of Head and Neck business.industry Organic Chemistry Drug Synergism General Medicine phytochemicals medicine.disease Head and neck squamous-cell carcinoma Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Head and Neck Neoplasms Chemoprotective Cancer research Female Cisplatin business medicine.drug |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 8547, p 8547 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21228547 |
| Popis: | The present review summarizes the most recent studies focusing on the synergistic antitumor effect of the physiological methyl donor S-adenosylmethionine (AdoMet) in association with the main drugs used against breast cancer and head and neck squamous cell carcinoma (HNSCC), two highly aggressive and metastatic malignancies. In these two tumors the chemotherapy approach is recommended as the first choice despite the numerous side effects and recurrence of metastasis, so better tolerated treatments are needed to overcome this problem. In this regard, combination therapy with natural compounds, such as AdoMet, a molecule with pleiotropic effects on multiple cellular processes, is emerging as a suitable strategy to achieve synergistic anticancer efficacy. In this context, the analysis of studies conducted in the literature highlighted AdoMet as one of the most effective and promising chemosensitizing agents to be taken into consideration for inclusion in emerging antitumor therapeutic modalities such as nanotechnologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |