Tumor size as a prognostic factor in limited-stage thymic epithelial tumors: A multicenter analysis
| Autor: | Jae Kwang Yun, Hyeong Ryul Kim, Dong Kwan Kim, Young Mog Shim, Young Tae Kim, Kyung Young Chung, Geun Dong Lee, Su Kyung Hwang, Sehoon Choi, Yong-Hee Kim, Seung-Il Park, Sumin Shin, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Il Zo, Samina Park, Kwan Yong Hyun, Yoohwa Hwang, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Chang Young Lee, Jin Gu Lee, Hyo Chae Paik, Dae Joon Kim |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Prognostic factor Optimal cutoff 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors Internal medicine medicine Overall survival Humans In patient Neoplasms Glandular and Epithelial Stage (cooking) Neoplasm Staging Retrospective Studies Limited Stage Tumor size business.industry Thymus Neoplasms Middle Aged 030228 respiratory system Proper treatment Female Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 162:309-317.e9 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/j.jtcvs.2020.05.048 |
| Popis: | The prognostic significance of tumor size in thymic epithelial tumors (TETs) has not been fully evaluated. We aimed to clarify the prognostic value of tumor size in limited-stage and advanced-stage TETs.Clinical records of patients with completely resected TETs were retrospectively collected from 4 tertiary centers between January 2000 and February 2013. Information on the Masaoka-Koga stage was available for 1215 patients (M-K group), and 433 patients were classified according to the eighth edition of the Tumor-Node-Metastasis staging system (TNM group). Limited-stage and advanced-stage TETs were defined according to whether they were confined within the surrounding fatty tissues without invasion. The optimal cutoff value was selected using a maximally selected log-rank statistic.The median tumor size was 6.0 ± 2.8 cm in the M-K group and 6.5 ± 3.0 cm in the TNM group. In the multivariable analysis, tumor size had a significant effect on both overall survival (P = .003) and recurrence-free survival (P .001) for limited-stage tumors (M-K stage I or II or TNM stage I), but not for advanced-stage tumors (M-K stage III or IV or TNM stage II-IV; P = .349 for overall survival and P = .439 for recurrence-free survival). The optimal cutoff value for tumor size was5.5 cm for both overall survival and recurrence-free survival in limited-stage TETs.Tumor size is an independent prognostic factor in patients with completely resected limited-stage TETs and a cutoff value5.5 cm might help clinicians enact proper treatment strategies and surveillance. |
| Databáze: | OpenAIRE |
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