Magnesium-Flush Infusion into the Aortic Root Just before Reperfusion Reduces the Requirement for Internal Defibrillation and Early Post-Perfusion Arrhythmias
| Autor: | Bülent Tünerir, Yavuz Beşoğul, Caner Ozdemir, Recep Aslan |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Ventricular Tachyarrhythmias Defibrillation Aortic root medicine.medical_treatment Electric Countershock Ischemia chemistry.chemical_element Myocardial Reperfusion Injury Placebo Biochemistry law.invention Postoperative Complications Double-Blind Method law Internal medicine Cardiopulmonary bypass Humans Medicine Magnesium Prospective Studies Aorta Aged Cardiopulmonary Bypass business.industry Biochemistry (medical) Arrhythmias Cardiac Cell Biology General Medicine Middle Aged medicine.disease chemistry Anesthesia Cardiology Female business Perfusion |
| Zdroj: | Journal of International Medical Research. 31:202-209 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000303100306 |
| Popis: | Pre- and post-operative administration of magnesium has beneficial effects on post-operative ischaemia and reperfusion arrhythmias, but few studies have examined whether intra-operatively administered magnesium can prevent the effects of intra-operative arrhythmias. The aim of this randomized, double-blind study was to compare the effects of intra-operative magnesium or placebo on intra-operative arrhythmias in patients undergoing coronary bypass grafting. Patients received a flush infusion of magnesium or placebo into the aortic root before cross-clamp removal. The results showed that rate of spontaneous resumption of a cardiac rhythm was significantly higher, and number of shocks for defibrillation, energy requirement for defibrillation and rate of intra-operative ventricular tachyarrhythmias were significantly lower in the magnesium group, compared with the placebo group. The differences in need for temporary pacing, and in serum magnesium levels, were not significant. Intra-operative administration of magnesium has beneficial effects on the outcome of surgery. Larger, multicentre clinical investigations should now be undertaken. |
| Databáze: | OpenAIRE |
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