Reduction in serotonin 5HT2 receptor binding on platelets of delinquent adolescents
| Autor: | Sam Tyano, Rachel Blumensohn, Nachman Greuner, Abraham Weizman, Alan Apter, Gideon Ratzoni, Malka Israeli, Anat Biegon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Ketanserin Adolescent Poison control Binding Competitive Developmental psychology Age Distribution Internal medicine medicine Juvenile delinquency Humans Platelet Receptor Child 5-HT receptor Pharmacology 5-HT2 receptor Age Factors Aggression Endocrinology Receptors Serotonin Juvenile Delinquency Serotonin Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 118(3) |
| ISSN: | 0033-3158 |
| Popis: | The possible involvement of serotonin receptors of the 5HT2 type in aggressive behavior was studied in juvenile delinquents. A group of 28 delinquent adolescents (13-18 years old) who had committed violent crimes was compared with a group of age matched controls. Subjects were drug and medication free during the study. 5HT2 receptors were labeled on platelet membranes using tritiated ketanserin. Receptor binding in the delinquent adolescents was significantly lower than in age matched controls. Mean +/- SD of 76 controls was 32.3 +/- 14.2 fm/mg, compared to 16.6 +/- 8.2 fm/mg in 28 delinquents (P0.002, Student's t-test). These results support a role for serotonin in general and 5HT2 receptors in particular in human aggressive behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink