Organochlorine pesticide levels in Greek patients with Parkinson’s disease
| Autor: | Christos Hadjichristodoulou, Vasileios Siokas, Leonidas Stefanis, Michalis Koureas, Evagelos Sakalakis, Martin F. Wilks, Efthimios Dardiotis, Georgia Xiromerisiou, Efthymia Petinaki, Athina-Maria Aloizou, Georgios M. Hadjigeorgiou, Aristidis Tsatsakis |
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| Rok vydání: | 2020 |
| Předmět: |
Parkinson's disease
Heptachlor Health Toxicology and Mutagenesis Physiology 010501 environmental sciences AD Alzheimer’s disease Toxicology Logistic regression 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:RA1190-1270 Environmental factors medicine organochlorines lcsh:Toxicology. Poisons PD Parkinson’s disease 0105 earth and related environmental sciences OC organochlorines business.industry Confounding Regular Article Hexachlorobenzene Odds ratio Pesticide medicine.disease Confidence interval chemistry Parkinson’s disease PD business 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 7, Iss, Pp 596-601 (2020) |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2020.03.011 |
| Popis: | Background Parkinson’s disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are a class of widely-used pesticides that have been included among the list of environmental factors incriminated in PD pathogenesis. However, most studies reporting this association are based on questionnaires, and few have reported exposure data. Aim To examine the relationship between OC blood concentrations and PD risk. Methods In the present study, we studied the concentrations of 8 OC compounds (hexachlorobenzene, heptachlor, hepachlor epoxide, c-chlordane, a-chlordane, p,p’-DDE, DDD, DDT) in 104 Greek PD patients and 110 healthy controls. Results All substances studied were present in at least one sample. The most frequently detected (above the level of quantification) pesticides were p,p’-DDE (n = 214, 100 % of both groups) and hexachlorobenzene, HCB (n = 189, cases 46.5 %, controls 53.5 %). Higher levels of DDE were detected among PD patients in comparison to controls by using logistic regression analysis to control for confounders [Odds Ratio, OR (95 % confidence interval, C.I.)]: 2.592,(1.29–5.21)], whilst lower levels of HCB were detect among PD patients [OR,95 %CI:0.176(0.09−0.35)]. Conclusions Our data suggest that exposure to specific OCs is related to the risk of PD. Further studies, using real exposure data, are needed in order to confirm and extend these findings. |
| Databáze: | OpenAIRE |
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