Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear
| Autor: | Nerissa Kirkwood, Modesta Blunskyte, Camille H. Tardieu, Nicholas Boyd-Gibbins, Joerg T. Albert, Jason Somers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Molecular biology Science Sensory system 02 engineering and technology Article Sensory neuroscience 03 medical and health sciences Transcriptional regulation otorhinolaryngologic diseases Drosophila Multidisciplinary biology 021001 nanoscience & nanotechnology biology.organism_classification 3. Good health Biological sciences 030104 developmental biology Drosophila melanogaster 0210 nano-technology Transduction (physiology) Neuroscience Homeostasis Function (biology) |
| Zdroj: | iScience, Vol 24, Iss 5, Pp 102486-(2021) iScience |
| ISSN: | 2589-0042 |
| Popis: | Summary Across their lives, biological sensors maintain near-constant functional outputs despite countless exogenous and endogenous perturbations. This sensory homeostasis is the product of multiple dynamic equilibria, the breakdown of which contributes to age-related decline. The mechanisms of homeostatic maintenance, however, are still poorly understood. The ears of vertebrates and insects are characterized by exquisite sensitivities but also by marked functional vulnerabilities. Being under the permanent load of thermal and acoustic noise, auditory transducer channels exemplify the homeostatic challenge. We show that (1) NompC-dependent mechanotransducers in the ear of the fruit fly Drosophila melanogaster undergo continual replacement with estimated turnover times of 9.1 hr; (2) a de novo synthesis of NompC can restore transducer function in the adult ears of congenitally hearing-impaired flies; (3) key components of the auditory transduction chain, including NompC, are under activity-dependent transcriptional control, likely forming a transducer-operated mechanosensory gain control system that extends beyond hearing organs. Graphical abstract Highlights • De novo NompC synthesis restores auditory transduction in congenitally deafened flies. • Complete turnover of NompC mechanotransducers within less than 24 hr. • Activity-dependent transcriptional control of transducers controls auditory function. Biological sciences ; Molecular biology ; Sensory neuroscience |
| Databáze: | OpenAIRE |
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