The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential
| Autor: | David P. Berry, Christopher D. Mann, Will P. Steward, Ashley R. Dennison, M'Balu A. Webb, Laura Spencer, Daniel Spencer, Matthew S. Metcalfe, Cristina Pollard |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
Docosahexaenoic Acids Angiogenesis medicine.medical_treatment Angiogenesis Inhibitors Diet Mediterranean Mice chemistry.chemical_compound Neoplasms Fatty Acids Omega-3 Tumor Cells Cultured medicine Animals Humans Unsaturated fatty acid Neovascularization Pathologic biology Growth factor Eicosapentaenoic acid Rats Angiogenesis inhibitor Gene Expression Regulation Neoplastic Vascular endothelial growth factor Eicosapentaenoic Acid Oncology chemistry Docosahexaenoic acid Immunology Cancer research biology.protein Platelet-derived growth factor receptor |
| Zdroj: | European Journal of Cancer. 45:2077-2086 |
| ISSN: | 0959-8049 |
| Popis: | Omega-3 fatty acid (omega-3 FA) consumption has long been associated with a lower incidence of colon, breast and prostate cancers in many human populations. Human trials have demonstrated omega-3 FA to have profound anti-inflammatory effects in those with cancer. In vitro and small animal studies have yielded a strong body of evidence establishing omega-3 FA as having anti-inflammatory, anti-apoptotic, anti-proliferative and anti-angiogenic effects. This review explores the evidence and the mechanisms by which omega-3 FA may act as angiogenesis inhibitors and identifies opportunities for original research trialling omega-3 FAs as anti-cancer agents in humans. The conclusions drawn from this review suggest that omega-3 FAs in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found principally in oily fish have potent anti-angiogenic effects inhibiting production of many important angiogenic mediators namely; Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Platelet-Derived Endothelial Cell Growth Factor (PDECGF), cyclo-oxygenase 2 (COX-2), prostaglandin-E2 (PGE2), nitric oxide, Nuclear Factor Kappa Beta (NFKB), matrix metalloproteinases and beta-catenin. |
| Databáze: | OpenAIRE |
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