Combined effect of obstructive sleep apnea and chronic smoking on cognitive impairment
| Autor: | Xiu Juan Zhang, Qing Yun Li, Li Na Zhou, Qiong Wang, Ying Ni Lin, Hua Jun Xu |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Polysomnography medicine.medical_treatment Statistics as Topic Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Cigarette smoking Surveys and Questionnaires medicine Humans Cognitive Dysfunction Cognitive impairment Sleep Apnea Obstructive business.industry Smoking Cognition Tobacco Use Disorder Middle Aged medicine.disease respiratory tract diseases Obstructive sleep apnea 030228 respiratory system Otorhinolaryngology Physical therapy Smoking cessation Smoking Cessation Neurology (clinical) business Clock drawing test 030217 neurology & neurosurgery |
| Zdroj: | Sleep and Breathing. 20:51-59 |
| ISSN: | 1522-1709 1520-9512 |
| Popis: | Little is known about combined effect of obstructive sleep apnea (OSA) and chronic smoking on cognitive impairment. We aimed to determine whether smoking synergizes with OSA in deteriorating cognitive function and whether smoking cessation contributes to cognitive benefits.One hundred and eighteen male patients were enrolled in the study and asked to complete neurocognitive function tests including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), clock drawing test (CDT), and verbal fluency test (VFT). Variables of those neurocognitive function tests were analyzed with two factors: OSA and smoking.After adjustment of potential confounding factors, an OSA-by-smoking interaction was found in CDT-C scores and a main smoking effect were showed in MoCA scores. Smoking patients with OSA had the worst performance in the four tests compared with the other three groups (smoking patients without OSA, non-smoking patients with and without OSA). Ex-smokers with OSA tended to perform better than current smokers, but still worse than never-smokers with OSA in those tests.The results suggested that the coexistence of OSA and chronic smoking resulted in more pronounced cognitive deficits than either factor along. Smoking cessation may benefit cognitive function to some extents in patients with OSA. |
| Databáze: | OpenAIRE |
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