Head and neck cancer: Value of perfusion CT in depicting primary tumor spread
| Autor: | Piotr Trojanowski, Agnieszka Trojanowska, Janusz Klatka, Tomasz Jargiełło, Andrzej Drop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood volume Sensitivity and Specificity Clinical Research squamous cell cancer Carcinoma medicine Humans Prospective Studies functional imaging Aged business.industry Head and neck cancer General Medicine Blood flow Middle Aged medicine.disease Primary tumor Head and Neck Neoplasms CT perfusion Carcinoma Squamous Cell Female Tomography Radiology business Tomography X-Ray Computed Infiltration (medical) Perfusion |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | Summary Background: The aim of this study was to assess head and neck squamous cell cancer and surrounding tissue in computed tomography contrast enhanced and perfusion studies, and to examine the role of per-fusion imaging in depiction of tissue infiltration. Material/Methods: We prospectively evaluated 43 primary malignant head and neck tumors, using standard CT fol-lowed by perfusion. Blood flow, blood volume, mean transit time, and permeability values were obtained using regions of interest (ROIs) over lesions and surrounding tissue. Results were com-pared with histological analysis of resected tissue. Sensitivity, specificity, accuracy, positive and neg -ative predictive values were calculated for both methods. Results: We found significant differences between infiltrated and non-infiltrated tissue, especially with re-gard to muscles. In case of bone and salivary gland infiltration, change in perfusion parameters did not allow proper diagnosis. Conclusions: CTP shows promise in depicting malignant infiltration. The combined use of CECT plus CTP re-sults in correct staging of the majority of head and neck tumors. |
| Databáze: | OpenAIRE |
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