Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists

Autor:	Mohammad Sarwar Alam, Keshav Naik, Ajay Soni, Sreeji Nair, Mohammad Salman, Ian Anthony Cliffe, Abhijit Ray, Viswajanani J. Sattigeri, Rauf Abdul Rehman Abdul, Sunanda G. Dastidar, Venkata Palle
Rok vydání:	2010
Předmět:	Models Molecular medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Integrin alpha4beta1 Ring (chemistry) Biochemistry Chemical synthesis Cell Line Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Humans Proline Receptor Molecular Biology Chemistry Organic Chemistry Dioxolanes Biological activity Affinities Molecular Medicine Bioisostere Protein Binding
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 20:5514-5520
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2010.07.069
Popis:	A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d012c7b4c6f5653f197a76709ddb57f2 https://doi.org/10.1016/j.bmcl.2010.07.069 Zobrazit plný text záznamu Full Text from ScienceDirect