IgA deficiency and SLE: prevalence in a clinic population and a review of the literature
| Autor: | E. C. C. Rankin, David A. Isenberg |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Immunoglobulin A Anti-nuclear antibody West Indies Population Human leukocyte antigen 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Rheumatology HLA Antigens immune system diseases London Prevalence Humans Lupus Erythematosus Systemic Medicine Allele skin and connective tissue diseases education Alleles Autoantibodies 030203 arthritis & rheumatology education.field_of_study Lupus erythematosus biology business.industry IgA Deficiency Autoantibody Middle Aged medicine.disease Antibodies Antinuclear Immunology biology.protein Female Antibody business |
| Zdroj: | Lupus. 6:390-394 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/096120339700600408 |
| Popis: | An association between systemic lupus erythematosus (SLE) and immunoglobulin A (IgA) deficiency has been reported previously and may have therapeutic consequences for patients who require treatment with intravenous immunoglobulin. We report the prevalence of IgA deficiency in a clinic population of 96 patients with SLE. Five patients were found to be consistently IgA deficient. These patients were more likely to be West Indian, to have anti-Sm and anti-La antibodies and to have a speckled pattern of antinuclear antibody. There were no significant differences in clinical features between IgA deficient and other SLE patients, nor in SLE-related HLA alleles. We thus confirm the increased prevalence of IgA deficiency in patients with SLE. A review of the literature is presented and we speculate on the nature of the link between IgA deficiency and SLE. |
| Databáze: | OpenAIRE |
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